This session will explore in-depth case studies of two interdisciplinary centers for STEM learning, innovation, and entrepreneurship, one at a leading liberal arts college (Washington and Lee University), and the other at a large research university (Virginia Commonwealth University). Leaders involved in the planning, design, operation, and evolution of two successful STEM and innovation centers will share the most impactful decisions affecting the long-term success of their work, including how location, governance, funding, programming, and promotion influence dynamic interdisciplinary results.