According to this Innovation Showcase item from the League for Innovation, Project Lead the Way is one of the most successful secondary-level STEM programs:

Project Lead The Way (PLTW), is being supported by a growing number of community colleges as a robust and well-proven curriculum that integrates effectively with their own paths of study. Through increased cooperation with PLTW high schools and engineering universities, a number of community colleges have expanded their own STEM offerings to provide students the comprehensive education they need for technology-oriented careers ... .

Project Lead The Way was conceived in the early 1990s as a way to reverse the decline in students choosing engineering and technology-oriented careers. PLTW courses emphasize applied learning and help prepare students for life in the 21st century, whether or not they choose to work in technical fields. This hands-on approach gives students the opportunity to apply math and science concepts to a variety of real-world problems that are challenging and fun.